Creating stable stem regions for loop elongation in Fcabs - Insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations

Article ID	Journal	Published Year	Pages	File Type
10537550	Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics	2014	11 Pages	PDF

Keywords

DSC FACS mAb ADCC CDC FcγRI scFv IgG1 antibody dependent cell-mediated cytotoxicity Monoclonal antibody Molecular dynamics Molecular dynamics simulation Fab fluorescence activated cell sorting antigen binding fragment single-chain variable fragment Protein engineering complement dependent cytotoxicity yeast surface display Differential scanning calorimetry

Related Topics

Physical Sciences and Engineering Chemistry Analytical Chemistry

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Creating stable stem regions for loop elongation in Fcabs - Insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations

Authors

Christoph Hasenhindl, Balder Lai, Javier Delgado, Michael W. Traxlmayr, Gerhard Stadlmayr, Florian Rüker, Luis Serrano, Chris Oostenbrink, Christian Obinger,