| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10538789 | Food Chemistry | 2012 | 11 Pages |
Abstract
⺠QT, K and M inhibited CYP1 activity dose-dependently with IC50s ranging from 2.2 to 4 μM; AF was inactive. ⺠CYP1A1 protein amount was decreased in cells co-treated with TCDD and QT, K or M compared to TCDD alone. ⺠Relatively higher basal CYP1B1 protein was not significantly affected by flavonoid treatments. ⺠Significant inhibition of induced CYP1A1 or CYP1B1 mRNA was not detected following flavonoid cotreatment. ⺠Mechanisms of CYP1 inhibition in this cell line are complex and dependent on the CYP gene, AhR inducer and the flavonoid.
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Authors
Zankhana Master, Amit Chaudhary, Thomas R. Sutter, Kristine L. Willett,