| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10539584 | Food Chemistry | 2012 | 6 Pages |
Abstract
⺠Inhibition of CETP is expected to alleviate atherosclerosis by its affect on HDL-cholesterol. ⺠We demonstrated that hop-derived xanthohumol had a potent CTEP inhibitory property. ⺠Its IC50 value was approximately 31.2 μg/ml (88.0 μM). ⺠Its inhibitory mechanism for the CETP reaction was mixed, non competitive. ⺠Its chalcone structure and prenyl group were essential for its CETP inhibitory action.
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Authors
Hiroshi Hirata, Koji Takazumi, Shuichi Segawa, Yukio Okada, Naoyuki Kobayashi, Tatsuro Shigyo, Hitoshi Chiba,