Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10539892 | Food Chemistry | 2013 | 7 Pages |
Abstract
In this study, we performed in vitro and in vivo studies to examine whether a 70% ethanol extract of Prunus mume fruits (EMS) exhibits anti-diabetic effects. Treatment with EMS increased glucose uptake in C2C12 myotubes, and also increased PPAR-γ activity or PPAR-γ mRNA expression. To confirm these in vitro results, we next conducted an animal experiment. A high-fat diet significantly increased the body weight, fat accumulation, and glucose levels in mice. Under the same conditions, 5% EMS attenuated the high-fat diet-induced increase in body weight and fat accumulation and improved the impaired fasting glucose level and glucose tolerance. High performance liquid chromatography analysis demonstrated that EMS contained chlorogenic acid, caffeic acid, rutin, luteolin-7-glucoside, naringin, apigenin-7-glucoside, and hesperidin. Taken together, these findings suggest that EMS exerts an anti-diabetic effect both in vitro and in vivo, which is mediated, at least in part, by the activation of PPAR-γ.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Eun Ju Shin, Haeng Jeon Hur, Mi Jeong Sung, Jae Ho Park, Hye Jeong Yang, Myung Sunny Kim, Dae Young Kwon, Jin-Taek Hwang,