Article ID Journal Published Year Pages File Type
10539919 Food Chemistry 2013 8 Pages PDF
Abstract
Cultures of Escherichia coli 555 were grown at four levels of carvacrol (0-2 mM) and the E. coli endo-metabolome was extracted and measured by 1H NMR spectroscopy. The results show that glucose concentration is going up with concentration of carvacrol and so do formate until the highest concentration is reached, from which point it suddenly decreases. This is interpreted as if the bacteria are increasingly unable to further metabolize glucose and as if the bacteria increasingly shifts with higher levels of carvacrol toward sugar fermentation as carbon source, until the level of carvacrol reaches a level (2.00 mM), where the E. coli must give up. Additionally, the multivariate Principal Component Analysis suggests that the adaptation occurring at sub-lethal doses of carvacrol is different from that occurring at higher doses.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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