| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10541603 | Food Chemistry | 2012 | 7 Pages |
Abstract
⺠Leucocyte-type 12-lipoxygenase is the key enzyme for LDL oxidation and atherogenesis. ⺠We found that guava leaf extracts inhibited the catalytic activity of this enzyme. ⺠LDL oxidation by the enzyme-expressing cells was also suppressed by the extracts. ⺠Oral administration of the extracts decreased atherosclerosis in apoE-knockout mice. ⺠The active components in the extracts were identified as ethyl gallate and quercetin.
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Authors
Yuki Kawakami, Tomoko Hosokawa, Tomoko Morinaka, Shioka Irino, Shiori Hirano, Hirokazu Kobayashi, Akiko Yoshioka, Toshiko Suzuki-Yamamoto, Miyuki Yokoro, Masumi Kimoto, Hideaki Tsuji, Hiromi Yamashita, Shinobu Doi, Chikao Yutani, Rina Kato,