Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10542335 | Food Chemistry | 2013 | 7 Pages |
Abstract
In the antimutagenicity assays, these luteolin derivatives showed antimutagenic effects in deletion and intrachromosomal recombination events against ethyl methanesulfonate and acridine mutagen agents. In deletion events, the highest inhibition rates for luteolin-7-O-glucoside, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide against ethyl methanesulfonate were 57.6%, 58.3% and 62.5%, respectively. Likewise, the highest inhibition rates for luteolin-7-O-glucoside, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide against acridin were 21.8%, 22.4% and 23.6%, respectively. Our findings showed that these luteolin derivatives have stronger antimutagenic properties against ethyl methanesulfonate compared to the acridine mutagen agent.
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Authors
Furkan Orhan, Medine Gulluce, Hakan Ozkan, Lokman Alpsoy,