Anti-inflammatory effect of flavonoids isolated from Korea Citrus aurantium L. on lipopolysaccharide-induced mouse macrophage RAW 264.7 cells by blocking of nuclear factor-kappa B (NF-ÎºB) and mitogen-activated protein kinase (MAPK) signalling pathways

Article ID	Journal	Published Year	Pages	File Type
10543090	Food Chemistry	2011	8 Pages	PDF

Abstract

âº The flavonoids isolated from Korea Citrus aurantium L. âº We study the anti-inflammatory effect of flavonoids in LPS-activated macrophage RAW 264.7 cells. âº The flavonoids reduce LPS-induced COX-2, iNOS, TNF-Î± and IL-6 via NF-ÎºB and MAPK signal pathway. âº This study proved the anti-inflammatory activity of the flavonoids. âº The flavonoids can be a therapeutic agent for inflammatory diseases.

Keywords

Citrus aurantium L.inducible nitric oxide synthase Cyclooxygenase-2 Anti-inflammation Nuclear factor-kappa B (NF-κB)Mitogen-activated protein kinase (MAPK)

Related Topics

Physical Sciences and Engineering Chemistry Analytical Chemistry

Preview

Anti-inflammatory effect of flavonoids isolated from Korea Citrus aurantium L. on lipopolysaccharide-induced mouse macrophage RAW 264.7 cells by blocking of nuclear factor-kappa B (NF-ÎºB) and mitogen-activated protein kinase (MAPK) signalling pathways

Authors

Sang Rim Kang, Kwang Il Park, Hyeon Soo Park, Do Hoon Lee, Jin A Kim, Arulkumar Nagappan, Eun Hee Kim, Won Sup Lee, Sung Chul Shin, Moon Ki Park, Dae Yong Han, Gon Sup Kim,