Article ID Journal Published Year Pages File Type
10547936 Journal of Chromatography A 2005 5 Pages PDF
Abstract
Contactless conductivity detection is successfully demonstrated for the enantiomeric separation of basic drugs and amino acids in capillary electrophoresis (CE). Derivatization of the compounds or the addition of a visualization agent as for indirect optical detection schemes were not needed. Non-charged chiral selectors were employed, hydroxypropylated cyclodextrin (CD) for the more lipophilic basic drugs and 18-crown-6-tetracarboxylic acid (18C6H4) for the amino acids. Acidic buffer solutions based on lactic or citric acid were used. The detection limits were determined as 0.3 μM for pseudoephedrine as an example of a basic drug and were in the range from 2.5 to 20 μM for the amino acids.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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