Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10550071 | Journal of Chromatography B | 2005 | 9 Pages |
Abstract
A novel amide based chiral stationary phase m-[(+)-α-methyl benzyl carboxamide] XAD-4 has been synthesized by covalently linking R(+)-1-phenylethylamine to chloroformoyl Amberlite XAD-4 under weak alkaline conditions. The synthesized resin has been primarily characterized by m.p., elemental analysis and FT-IR and 13C NMR spectra. β-Blockers viz. atenolol, metoprolol, and propranolol were successfully separated into their enantiomers using a mixture of sodium acetate-acetic acid buffer (pH 4.1):acetonitrile (4:6, v/v) solution using the synthesized resin. Hydrogen bonding and Ï-Ï interactions are supposed to be the major analyte-chiral stationary phase interactions.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Y.K. Agrawal, R.N. Patel,