Article ID Journal Published Year Pages File Type
10550071 Journal of Chromatography B 2005 9 Pages PDF
Abstract
A novel amide based chiral stationary phase m-[(+)-α-methyl benzyl carboxamide] XAD-4 has been synthesized by covalently linking R(+)-1-phenylethylamine to chloroformoyl Amberlite XAD-4 under weak alkaline conditions. The synthesized resin has been primarily characterized by m.p., elemental analysis and FT-IR and 13C NMR spectra. β-Blockers viz. atenolol, metoprolol, and propranolol were successfully separated into their enantiomers using a mixture of sodium acetate-acetic acid buffer (pH 4.1):acetonitrile (4:6, v/v) solution using the synthesized resin. Hydrogen bonding and π-π interactions are supposed to be the major analyte-chiral stationary phase interactions.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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