Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10550128 | Journal of Chromatography B | 2005 | 5 Pages |
Abstract
We devised a sensitive and simple method for determination of bromide in whole blood and urine from humans using gas chromatography-mass spectrometry. Bromide was alkylated with pentafluorobenzyl p-toluenesulphonate in the mixture of acetone and phosphate buffer (pH 6.8). The derivative obtained was analyzed using gas chromatography-mass spectrometry with the positive-ion EI mode. The lower limit of detection for the compound was 1Â mg/l. The calibration curve for bromide was linear over the concentration range from 2 to 100Â mg/l. With use of this method, levels of bromide in whole blood and urine were determined in cases of poisoning by inhaled brominated hydrocarbons.
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Authors
Shigetoshi Kage, Keiko Kudo, Hideaki Ikeda, Akira Tsujita, Noriaki Ikeda,