Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10550222 | Journal of Chromatography B | 2005 | 5 Pages |
Abstract
A rapid and sensitive LC-MS-MS method for quantifying levodropropizine in human plasma after oral administration of a single-dose (60Â mg/day) was developed and validated. The sample preparation used liquid-liquid extraction with a mixture of dichloromethane-diethyl ether (2:3, v/v) in a basic environment. The retention time of levodropropizne and zolmitriptan (used as internal standard) was 1.6 and 1.4Â min, respectively. The assay was linear over the range 0.25-500Â ng/mL with a LOQ of 0.25Â ng/mL. The intra- and inter-day precision were <8.1% and <11.5%, respectively, and the accuracy was in the range 87.6-112%. The levodropropizine concentration profile in human plasma was determined.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Yunbiao Tang, Limei Zhao, Yingwu Wang, J. Paul Fawcett, Jingkai Gu,