Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10550515 | Journal of Chromatography B | 2005 | 11 Pages |
Abstract
Ecotoxicity assessment is essential before placing new chemical substances on the market. An investigation of the use of the chromatographic retention (log k) in biopartitioning micellar chromatography (BMC) as an in vitro approach to evaluate the toxicity in fish of pesticides (acute toxicity levels as pLC50) is proposed. A heterogeneous data set of 85 pesticides from six chemical families with available experimental fish toxicity data (ECOTOX database from U.S. Environmental Protection Agency (EPA)) was used. For pesticides exhibiting non-polar narcosis mechanism in fish (non-specific toxicity), more reliable models and precise pLC50 estimations are obtained from log k (quantitative retention-activity relationships, QRAR) than from log P (quantitative structure-activity relationships, QSAR) or ECOSAR (ECOSAR program from U.S. EPA).
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
José MarÃa Bermúdez-Saldaña, Laura Escuder-Gilabert, MarÃa José Medina-Hernández, Rosa MarÃa Villanueva-Camañas, Salvador Sagrado,