Article ID Journal Published Year Pages File Type
10553537 Journal of Pharmaceutical and Biomedical Analysis 2011 7 Pages PDF
Abstract
The LC method was then fully validated applying the strategy based on total measurement error and accuracy profiles. The accuracy profile obtained by linear regression after square root transformation was selected, the acceptance limits being settled at ±10% for the intended use of this analytical method. The relative bias was lower than 1.5%, while the RSD values for repeatability and intermediate precision were both below 1.0%. The limit of detection (LOD) and the limit of quantification (LOQ) were found to be about 0.2 and 1.0 μg/mL, respectively, corresponding to 0.02 and 0.1% of the enantiomeric impurity in S-ropivacaine.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
Authors
, , , , ,