Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10553544 | Journal of Pharmaceutical and Biomedical Analysis | 2011 | 7 Pages |
Abstract
Both PDE-5 inhibitors and nitrosamines cause vasodilatation by increasing levels of NO. To their coincidental use is warned against because it may cause a fatal drop in blood pressure. In addition, nitrosamines are known carcinogens. This is the first time a PDE-5 inhibitor and a potential NO donor were identified in one molecule. The findings indicate the dangerous level of advancement in medicinal chemistry by producers of unapproved drugs.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
B.J. Venhuis, G. Zomer, M. Hamzink, H.D. Meiring, Y. Aubin, D. de Kaste,