Article ID Journal Published Year Pages File Type
10553544 Journal of Pharmaceutical and Biomedical Analysis 2011 7 Pages PDF
Abstract
Both PDE-5 inhibitors and nitrosamines cause vasodilatation by increasing levels of NO. To their coincidental use is warned against because it may cause a fatal drop in blood pressure. In addition, nitrosamines are known carcinogens. This is the first time a PDE-5 inhibitor and a potential NO donor were identified in one molecule. The findings indicate the dangerous level of advancement in medicinal chemistry by producers of unapproved drugs.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
Authors
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