Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10553575 | Journal of Pharmaceutical and Biomedical Analysis | 2011 | 6 Pages |
Abstract
A sildenafil analogue was detected and isolated from a health supplement claimed for human use. The structure of this new analogue was elucidated using LC-UV, LC-Orbitrap-MS, IR spectroscopy, 1D and 2D NMR. It was characterized as dithio-desmethylcarbodenafil containing 2 thiocarbonyl groups instead of 2 carbonyl groups, and 4-methyl substitution, on the piperazine ring, rather than 4-ethyl substitution, when compared to sildenafil.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Xiaowei Ge, Lin Li, Hwee-Ling Koh, Min-Yong Low,