Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10553988 | Journal of Pharmaceutical and Biomedical Analysis | 2005 | 7 Pages |
Abstract
Mebendazole is a common benzimidazole anthelmintic that is water insoluble. It is reported to exist in three different polymorphic forms in the solid state, i.e. polymorph A, B and C. Form C is the pharmaceutically preferred form because of its increased aqueous solubility. This paper deals with the use of variable-temperature X-ray powder analysis (VTXRPD) to study the transformation of Form C. Results showed that Form C was stable and transformed to the more stable polymorph A at high temperature (>180 °C). This transformation is a first-order process with activation energy of 238 ± 16 kJ/mole. Further studies showed that compression did not cause any significant changes in the crystal structure of polymorph C.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Melgardt M. de Villiers, Rudolf J. Terblanche, Wilna Liebenberg, Erna Swanepoel, Theo G. Dekker, Mingna Song,