| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10554015 | Journal of Pharmaceutical and Biomedical Analysis | 2005 | 8 Pages |
Abstract
Water-in-oil microemulsion electrokinetic chromatography has been applied to the separation of a range of acids, bases and neutrals and is especially suitable for very water-insoluble drug compounds. A number of operating parameters were evaluated. An optimised set of operating conditions allowed separation of a range of pharmaceutical formulations containing water-insoluble compounds. A number of novel applications for W/O microemulsions were developed and ability to quantify drug contents in tablets and a cream was shown with good precision, detector linearity and accuracy. Comparison of obtained data with those determined from a HPLC method showed acceptable agreement.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Margo Broderick, Sheila Donegan, Joe Power, Kevin Altria,