| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10554097 | Journal of Pharmaceutical and Biomedical Analysis | 2005 | 6 Pages |
Abstract
In the present work, the relationship between residual solvents concentration and ampicillin trihydrate crystals stability has been investigated. The amounts of residual solvents determined by GC, X-ray powder diffraction (XRPD) and Fourier transform infrared spectroscopy (FT-IR) were used for characterization of solid state. The obtained results have shown good relationship between concentration of methylene chloride (as a critical residue solvent) and degree of ampicillin trihydrate crystallinity. As with the increasing methylene chloride concentration in the sample the degree of crystallinity decreased after stability test. From this relationship, critical concentration of methylene chloride into the ampicillin trihydrate is obtained and the results can be used for improving the large-scale production of ampicillin trihydrate.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Saeed Nojavan, Alireza Ghassempour, Yosef Bashour, Masoud Khalilian Darbandi, Seyyed Hamid Ahmadi,