| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10554121 | Journal of Pharmaceutical and Biomedical Analysis | 2005 | 6 Pages |
Abstract
IC50 values of selective prenyl transferase inhibitors, B-581, FTI 276 and GGTI 287 have been measured to 34, 0.8 and 18Â nM, respectively, using dansyl-GCVLS as substrate (FTase inhibition). When dansyl-GCVLL is used as substrate (GGTase inhibition) the IC50 values are 5100, 75 and 5Â nM for B-581, FTI 276 and GGTI 287, respectively. Then, this developed method allowed to evaluate the selectivity of all the three inhibitors tested.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Laurence Goossens, Sophie Deweer, Jean Pommery, Jean-Pierre Hénichart, Jean-François Goossens,