Article ID Journal Published Year Pages File Type
10554214 Journal of Pharmaceutical and Biomedical Analysis 2005 5 Pages PDF
Abstract
An effective method based on capillary electrophoresis (CE) for the determination of netilmicin sulphate in commercial ophthalmic formulations was developed and validated. The use of a polymer-coated capillary and a non-absorbing running buffer permitted the elution of netilmicin in cationic mode at pH 3.0 and with direct UV detection at λ = 195 nm. Since pre-treatment of the samples is not required, this procedure may be straightforwardly applied to the other aminoglycosides provided that their extinction coefficient is not too low.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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