Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10554438 | Journal of Pharmaceutical and Biomedical Analysis | 2005 | 4 Pages |
Abstract
A spectrophotometric method is described for the determination of oxiconazole in raw material and in topical lotion. This method is based on the reaction of the oxiconazole with methyl orange in buffered aqueous solution of citric acid at pH 2.3. The chromogen, being extractable with dichloromethane, could be measured quantitatively with maximum absorption at 427 nm. The Lambert-Beer law was obeyed in the concentration range of 4.0-14.0 μg mlâ1. A prospective validation of the method showed that the method was linear (r = 0.9995), precise (intra-day: CV = 1.57% and inter-day: CV = 1.50%) and accurate (mean recoveries: 99.69%). The results compared favourably with those of the HPLC method.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Julie Milano, Simone Gonçalves Cardoso,