Article ID Journal Published Year Pages File Type
10554438 Journal of Pharmaceutical and Biomedical Analysis 2005 4 Pages PDF
Abstract
A spectrophotometric method is described for the determination of oxiconazole in raw material and in topical lotion. This method is based on the reaction of the oxiconazole with methyl orange in buffered aqueous solution of citric acid at pH 2.3. The chromogen, being extractable with dichloromethane, could be measured quantitatively with maximum absorption at 427 nm. The Lambert-Beer law was obeyed in the concentration range of 4.0-14.0 μg ml−1. A prospective validation of the method showed that the method was linear (r = 0.9995), precise (intra-day: CV = 1.57% and inter-day: CV = 1.50%) and accurate (mean recoveries: 99.69%). The results compared favourably with those of the HPLC method.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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