| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10554453 | Journal of Pharmaceutical and Biomedical Analysis | 2005 | 7 Pages |
Abstract
Diltiazem (DTZ) is an optically active calcium channel blocker having a benzodiazepine structure. The drug used in therapy is (+)-cis-diltiazem with configuration (2S,3S). To describe the analytical profile of DTZ different stationary phases (RP-18, RP-8, monolithic support) were tested. The best separation of DTZ from A, B, E and F was obtained using as stationary phase a RP-8 or a monolithic RP-18. The characterization of impurities was carried out using two analytical systems, HPLC and HPLC/MS.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
M.G. Quaglia, E. Donati, S. Fanali, E. Bossù, A. Montinaro, F. Buiarelli,