| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10556124 | Journal of Proteomics | 2011 | 21 Pages |
Abstract
⺠We confirmed that DHA-supplementation triggered the onset of apoptosis in PACA44 cell lines at 48 to 72h from the treatment. ⺠We performed differential proteomics analyses which yielded identification of 26 differentially-expressed proteins. ⺠In silico analyses highlighted that these proteins were mainly involved in structural changes and metabolism modulation. ⺠MS-based metabolomics evidenced a switch towards the pentose phosphate pathway and Krebs cycle. ⺠DHA-triggered apoptosis in PACA44 cells might be related to the metabolic modulation.
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Authors
Angelo D'Alessandro, Gian Maria D'Amici, Anna Maria Timperio, Nicolò Merendino, Lello Zolla,