Article ID Journal Published Year Pages File Type
10556197 Journal of Proteomics 2011 18 Pages PDF
Abstract
► Nephrotoxicity is an adverse effect that limits the use of calcineurin inhibitors in solid organ transplantation. ► Using SILAC we studied cyclosporine-induced proteomic perturbations in human renal cells. ► Cyclosporine but not tacrolimus specifically activates both ER stress and the Basigin-Cyclophilins pathway. ► A number of cyclosporine-related changes in protein expression are corrected by co-administration of N-acetylcysteine. ► This work raises new directions for future research in the field of calcineurine inhibitors nephrotoxicity.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
Authors
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