| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10556206 | Journal of Proteomics | 2012 | 11 Pages |
Abstract
⺠In brain mitochondria of STZ diabetic rats a severe decrement of the Ndufs3 subunit of complex I subunit is found. ⺠The mRNA level of Ndufs3 is also reduced in type-1 diabetic rat brain. ⺠The depressed expression of the Ndufs3 subunit is associated with a strong decrement of the catalytic activity of complex I. ⺠The severe impairment of the complex I activity can represent a critical factor to the onset of the diabetic encephalopathy.
Related Topics
Physical Sciences and Engineering
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Authors
Federica Taurino, Eleonora Stanca, Luisa Siculella, Raffaella Trentadue, Sergio Papa, Franco Zanotti, Antonio Gnoni,