Insight into the neuroproteomics effects of the food-contaminant non-dioxin like polychlorinated biphenyls

► Food-contaminant PCBs alter the proteome profile of rat cerebellar neurons. ► A state-of-the-art label-free semi-quantitative mass-spectrometry approach was used. ► Major targets include proteins involved in CREB, ubiquitin, cytoskeleton pathways. ► PCB congeners interfere with synaptic proteins both in vitro and in vivo. ► Implication of the findings to PCB neurodevelopmental toxicity.