| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10556264 | Journal of Proteomics | 2011 | 15 Pages |
Abstract
⺠Comparative 2-DIGE and MS reveals an impact of Tyk2 on the macrophage proteome. ⺠Tyk2 regulates enzymes involved in lipid and carbohydrate metabolism. ⺠Tyk2 regulates protein expression transcriptionally and post-transcriptionally. ⺠Poly(I:C) treatment induces a Tyk2-dependent increase of extracellular lactate. ⺠We provide evidence for a role of Tyk2 in linking metabolism and innate immunity.
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Authors
Tom Grunert, Nicole R. Leitner, Martina Marchetti-Deschmann, Ingrid Miller, Barbara Wallner, Marta Radwan, Claus Vogl, Thomas Kolbe, Dagmar Kratky, Manfred Gemeiner, Günter Allmaier, Mathias Müller, Birgit Strobl,