| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10556341 | Journal of Proteomics | 2011 | 15 Pages |
Abstract
⺠Global tyrosine phosphoproteome triggered by IL-2 in human lymphocytes was characterized. ⺠Molecular snapshot of IL-2 signaling led to identification of 172 phosphotyrosine effectors. ⺠Combinatorial site-specific phosphoproteomic analysis resulted in identification of 99 phosphorylated sites. ⺠Chemical inhibition of the analyzed IL-2-mediated signaling branches had distinct effects on lymphocyte proliferation.
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Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Nerea Osinalde, Helle Moss, Onetsine Arrizabalaga, Miren J. Omaetxebarria, Blagoy Blagoev, Ana M. Zubiaga, Asier Fullaondo, Jesus M. Arizmendi, Irina Kratchmarova,