Sub-proteomic study on macrophage response to Candida albicans unravels new proteins involved in the host defense against the fungus

► 3 Subcellular macrophage extracts were analyzed by 2D-DIGE and 26 proteins identified. ► 17 new proteins involved in the macrophage response to C. albicans were identified. ► There was a pro-inflammatory response and an increase in the oxidative stress. ► There was a reduction in the proteins involved in ER stress response. ► Galectin-3 increases in amount, secretion and its membrane allocation along the interaction.