| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10556501 | Journal of Proteomics | 2012 | 14 Pages |
Abstract
⺠Characterization of unusual truncated N-linked glycosylations of highly purified proteinase 3 (PR3). ⺠Characterization of a novel strong association of PR3 with granulocyte α-defensins and oligomers hereof. ⺠Proteins from neutrophil granules but not serum proteins were found to be associated with defensins. ⺠Role of PR3 glycosylation and its interplay with α-defensins in host defence and autoimmunity.
Keywords
HSATTRNHPPAR-2PABIFN-γPMNPMSFTFAFBPTTNDTTPR3ANCA5-bromo-4-chloro-3-indolyl phosphate/nitro blue tetrazoliumPNGase FmAbASPNMECNCIDN-glycosidase FtransthyretinBCIP/NBTMPOβ2-glycoprotein 1human serum albuminanti-neutrophil cytoplasmic antibodiesPolyclonal antibodiesEDTAAcetonitrileTrifluoroacetic acidFormic acidsodium dodecyl sulfate-polyacrylamide gel electrophoresisSDS-PAGEELISAEnzyme-linked immunosorbent assaycollision induced dissociationRoom temperaturedithiothreitolSerum Amyloid PSAPMass spectrometryphenylmethylsulfonyl fluoridepolymorphonuclear leukocytesMatrix-assisted laser desorption-ionizationMALDImyeloperoxidaseMonoclonal antibodiesfolate binding proteinproteinase 3human neutrophil peptideInterferon gammaWegener's granulomatosisGlycosylationProtease-activated receptor-2
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Morten Zoega, Tina Ravnsborg, Peter Højrup, Gunnar Houen, Christian Schou,