| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10559478 | Talanta | 2011 | 7 Pages |
Abstract
In our study we have identified phase I metabolites of cardiovascular and anti-ulcer agents with the application of predictive multiple reaction monitoring (pMRM) methods with liquid-chromatography-triple-quadrupole mass spectrometry (LC-QQQ-MS) in surface water samples. Targeted accurate mass spectrometry measurements were also carried out for confirmation with liquid-chromatography-time-of-flight mass spectrometry (LC-TOF-MS). pMRM followed by a targeted accurate mass spectrometry measurement can provide a sound basis for the selection of metabolites to be included in analytical methods for the investigation of environmental load of pharmaceuticals. Using LC-QQQ-MS twenty-one metabolites could be identified with two independent transitions at the same retention time and six of them could also be confirmed with LC-TOF-MS.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Renáta Varga, Zsuzsanna Eke, Kornél Torkos,