Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10559583 | Talanta | 2011 | 6 Pages |
Abstract
Flow injection analysis (FIA) with amperometric detection was employed for the quantification of N-acetylcysteine (NAC) in pharmaceutical formulations, utilizing an ordinary pyrolytic graphite (OPG) electrode modified with cobalt phthalocyanine (CoPc). Cyclic voltammetry was used in preliminary studies to establish the best conditions for NAC analysis. In FIA-amperometric experiments the OPG-CoPc electrode exhibited sharp and reproducible current peaks over a wide linear working range (5.0 Ã 10â5-1.0 Ã 10â3 mol Lâ1) in 0.1 mol Lâ1 NaOH solution. High sensitivity (130 mA molâ1 cm2) and a low detection limit (9.0 Ã 10â7 mol Lâ1) were achieved using the sensor. The repeatability (R.S.D.%) for 13 successive flow injections of a solution containing 5.0 Ã 10â4 mol Lâ1 NAC was 1.1%. The new procedure was applied in analyses of commercial pharmaceutical products and the results were in excellent agreement with those obtained using the official titrimetric method. The proposed amperometric method is highly suitable for quality control analyses of NAC in pharmaceuticals since it is rapid, precise and requires much less work than the recommended titrimetric method.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Iranaldo Santos da Silva, Marcelo Fernando Antão Araújo, Henrique Augusto Ferreira, Jaldyr de Jesus Gomes Jr., Sônia Maria Carvalho Neiva Tanaka, Auro Atsushi Tanaka, Lúcio Angnes,