Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10559653 | Talanta | 2009 | 10 Pages |
Abstract
A radial basis function neural network (RBFNN) method was developed for the first time to model the nonlinear calibration curves of four hexachlorocyclohexane (HCH) isomers, aiming to extend their working calibration ranges in gas chromatography-electron capture detector (GC-ECD). Other 14 methods, including seven parametric curve fitting methods, two nonparametric curve fitting methods, and five other artificial neural network (ANN) methods, were also developed and compared. Only the RBFNN method, with logarithm-transform and normalization operation on the calibration data, was able to model the nonlinear calibration curves of the four HCH isomers adequately. The RBFNN method accurately predicted the concentrations of HCH isomers within and out of the linear ranges in certified test samples. Furthermore, no significant difference (p > 0.05) was found between the results of HCH isomers concentrations in water samples calculated with RBFNN method and ordinary least squares (OLS) method (R2 > 0.9990). Conclusively, the working calibration ranges of the four HCH isomers were extended from 0.08-60 ng/ml to 0.08-1000 ng/ml without sacrificing accuracy and precision by means of RBFNN. The outstanding nonlinear modeling capability of RBFNN, along with its universal applicability to various problems as a “soft” modeling method, should make the method an appealing alternative to traditional modeling methods in the calibration analyses of various systems besides the GC-ECD.
Keywords
LOQECDGRNNANNsRMSERBFHCHOLSLDRBPNNRBFNNRSDANNPCNBLOQsm/zS/NElectron capture detectorI.S.internal standardElectron impactanalysis of varianceANOVAordinary least squaresRoot mean square errorSIMRadial basis function neural networkGeneralized neural networkArtificial Neural NetworkBack propagation neural networkartificial neural networkscoefficient of determinationCorrelation coefficientmass spectrometerRadial basis functionLODsLodLinear dynamic rangelimit of quantificationlimit of detectionMass-to-charge ratioSignal-to-noise ratioselected ion monitoringHexachlorocyclohexanePentachloronitrobenzeneGas chromatography
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Yanfei Chen, Jin He, Jibin Zhang, Ziniu Yu,