Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10560071 | Talanta | 2005 | 4 Pages |
Abstract
Quantitative assay of l-2-hydroxyglutaric acid (l-2-HGA) is important for the diagnosis of l-2-hydroxyglutaric aciduria. Three enantioselective, potentiometric membrane electrodes (EPMEs) based on maltodextrins with different dextrose equivalent (DE) (DE: 4.0-7.0 (I), 13.0-17.0 (II), 16.5-19.5 (III)), were designed for the enantioanalysis of l-2-HGA. The enantioselective, potentiometric membrane electrodes can be used reliably for enantiopurity assay of l-2-HGA using the direct potentiometric method in the ranges of 10â9-10â5, 10â6-10â3 and 10â8-10â5 mol Lâ1 for the enantioselective, potentiometric membrane electrodes based on maltodextrins I, II and III, respectively, with very low detection limits. A high reliability was obtained when the electrodes were used for the assay of l-2-HGA in urine samples.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
R'afat Mahmoud Nejem, Raluca-Ioana Stefan, Jacobus Frederick van Staden, Hassan Y. Aboul-Enein,