Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10560973 | Talanta | 2005 | 5 Pages |
Abstract
The validation parameters have shown good results: linearity of determination for both compounds including internal standard (ethylparaben) >0.999; repeatability of determination (R.S.D.) in the range 0.5-5.4% at three different concentration levels, detection limits in the range 0.5-2.0 μg mlâ1, and recovery from the pharmaceutical preparation in the range 99.3-99.9%. The chromatographic resolution between peak compounds was >5.0 and analysis time was <9 min under the optimal conditions. The method was found to be applicable for routine analysis of the active compounds ambroxol hydrochloride and doxycycline in various pharmaceutical preparations.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Dalibor Å atÃnský, Lucia M. L. Dos Santos, Hana SklenáÅová, Petr Solich, M.Conceição B.S.M. Montenegro, Alberto N. Araújo,