Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10561188 | Talanta | 2005 | 6 Pages |
Abstract
Electrochemical studies of famotidine were carried out using voltammetric techniques: cyclic voltammetry, linear sweep and square wave adsorptive stripping voltammetry. The dependence of the current on pH, buffer concentration, nature of the buffer, and scan rate was investigated. The best results for the determination of famotidine were obtained in MOPS buffer solution at pH 6.7. This electroanalytical procedure enabled to determine famotidine in the concentration range 1 Ã 10â9-4 Ã 10â8 mol Lâ1 by linear sweep adsorptive stripping voltammetry (LS AdSV) and 5 Ã 10â10-6 Ã 10â8 mol Lâ1 by square wave adsorptive stripping voltammetry (SW AdSV). Repeatability, precision and accuracy of the developed methods were checked. The detection and quantification limits were found to be 1.8 Ã 10â10 and 6.2 Ã 10â10 mol Lâ1 for LS AdSV and 4.9 Ã 10â11 and 1.6 Ã 10â10 mol Lâ1 for SW AdSV, respectively. The method was applied for the determination of famotidine in urine.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
SÅawomira Skrzypek, Witold Ciesielski, Adam SokoÅowski, Selahattin Yilmaz, Dorota Kaźmierczak,