Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10561435 | Talanta | 2005 | 6 Pages |
Abstract
The electrochemistry of metronidazole, 1-(hydroxyethyl)-2-methyl-5-nitroimidazole, was investigated at a carbon fiber microdisk electrode in pH 9 Britton Robinson buffer. Under these conditions, the reduction of metronidazole is controlled by both mass transport to the microdisk and adsorption with an equilibrium constant of 4 Ã 103 molâ1 dm3 and a saturation coverage of 0.88 Ã 10â8 mol cmâ2. The adsorption and accumulation of metronidazole on the surface of the carbon fiber allows its determination at low concentrations by square wave adsorptive stripping voltammetry. A detection limit for metronidazole of 5 Ã 10â7 mol dmâ3 and a R.S.D. of 3.7% at 1 Ã 10â6 mol dmâ3 (n = 4) were obtained with a two electrode system with no stirring during the accumulation step. Based on this method, a simple procedure for the determination of metronidazole in urine is described which requires no pre-treatment of the sample before analysis.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
P.N. Bartlett, E. Ghoneim, G. El-Hefnawy, I. El-Hallag,