| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10564379 | TrAC Trends in Analytical Chemistry | 2005 | 7 Pages |
Abstract
Transmembrane domains of integral membrane proteins present a formidable analytical challenge due to their general lack of polarity; recovery is enhanced by maintaining their association with polar-loop regions. Multi-dimensional separations of intact integral membrane proteins coupled with high-resolution electrospray-ionization mass spectrometers enable “top-down” proteomics, with coverage of bilayer domains.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Julian Whitelegge,