| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10564852 | Current Opinion in Chemical Biology | 2013 | 8 Pages |
Abstract
- Homologous protein recombination is both conservative and innovative.
- Structure and sequence information facilitates design of functional chimera libraries.
- Stability, enzyme substrate specificity, and optogenetic properties are included in the properties explored.
- Machine learning approaches can help navigate the fitness landscape to predict useful chimeras.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Devin L Trudeau, Matthew A Smith, Frances H Arnold,