Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10564868 | Current Opinion in Chemical Biology | 2013 | 9 Pages |
Abstract
Glycosaminoglycans (GAGs) participate in many critical biological processes by modulating the activities of a wide range of proteins, including growth factors, chemokines, and viral receptors. Recent studies using synthetic oligosaccharides and glycomimetic polymers have established the importance of specific structural determinants in controlling GAG function. These findings illustrate the power of synthetic molecules to elucidate glycan-mediated signaling events, as well as the prospect of further advancements to understand the roles of GAGs in vivo and explore their therapeutic potential.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Matthew E Griffin, Linda C Hsieh-Wilson,