Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10564902 | Current Opinion in Chemical Biology | 2013 | 7 Pages |
Abstract
⺠Not all chelators are the same: more than metal sequestration and elimination. ⺠Metal chelates can redistribute metals across biological membranes. ⺠Metal-chelating fragments provide leads for metalloenzyme inhibition. ⺠Metal chelation can enhance metal reactivity and thus cytotoxicity. ⺠Prochelators provide site-activated metal chelation and passivation.
Related Topics
Physical Sciences and Engineering
Chemistry
Chemistry (General)
Authors
Katherine J Franz,