| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10565376 | Current Opinion in Chemical Biology | 2013 | 6 Pages |
Abstract
Wyosine and its derivatives are highly modified, acid labile tricyclic bases found at position 37 of tRNAPhe in archaea and eukarya. The formation of the common 4-demethylwyosine structural feature entails condensation of pyruvate and N-methylguanosine catalyzed by TYW1. This review will focus on the mechanism of this complex radical mediated transformation.
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Authors
Anthony P Young, Vahe Bandarian,