Opportunities and challenges from current investigations into the biosynthetic logic of nosiheptide-represented thiopeptide antibiotics

- Nosiheptide is an archetypical thiopeptide antibiotic with a ribosomal origin.
- The complexity of thiopeptides arises from post-translational modifications.
- The biosynthetic logic of thiopeptides remains elusive.
- Nature combines common and specific decorations to afford thiopeptide molecules.
- Nosiheptide biosynthesis is a model system for appreciating the nature's strategy.