| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10569609 | Coordination Chemistry Reviews | 2013 | 10 Pages |
Abstract
⺠Purple acid phosphatase (PAP) is a target for novel anti-osteoporotic drugs. ⺠PAP requires a mixed-valent metal center (Fe3+-M2+) for activity. ⺠PAP is bifunctional, operating as a hydrolase and peroxidase. ⺠The proposed reaction mechanism for hydrolysis involves eight steps. ⺠Two nucleophilic hydroxides are available to initiate hydrolysis.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Gerhard Schenk, NataÅ¡a MitiÄ, Graeme R. Hanson, Peter Comba,