| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10571123 | Inorganica Chimica Acta | 2011 | 7 Pages |
Abstract
⺠The DNA interactions of two copper(II) complexes have been studied. ⺠They show binding affinity to CT DNA with binding constant (Kb) values in the order of 105 Mâ1. ⺠Thermal denaturation and circular dichroism studies suggest groove binding of the complexes to CT DNA. ⺠They also exhibit strong DNA cleavage activity in presence of reducing agents. ⺠Mechanistic studies reveal the involvement of reactive hydroxyl radicals for their DNA cleavage activity.
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Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Pankaj Kumar, Basudeb Baidya, Sumit Kumar Chaturvedi, Rizwan Hasan Khan, Debasis Manna, Biplab Mondal,