Article ID Journal Published Year Pages File Type
10572708 Journal of Fluorine Chemistry 2010 7 Pages PDF
Abstract
An alternative synthetic pathway to prepare norfloxacin analogues is presented. Three Lewis acids (CeCl3·7H2O, AlCl3·6H2O, ZnCl2) and one Brönsted acid (TsOH) were tested as catalysts in the preparation of 3,4-difluoroacrylate. Cyclization of this acrylate at 55 °C was achieved with the use of Eaton's reagent (P2O5/MeSO3H) a known Brönsted acid. The fluoroquinolone-boron complex presented high yields on C-7 nucleophilic substitution of the fluorine atom by different heterocyclic amines with low, medium and strong nucleophilic character.
Related Topics
Physical Sciences and Engineering Chemistry Inorganic Chemistry
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