| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10572829 | Journal of Fluorine Chemistry | 2005 | 4 Pages |
Abstract
A general synthesis of 2-fluoro-1-naphthols in two steps from 1-indanones is reported. The 1-indanones are first converted to difluoromethyl 2-fluoro-1-napthyl ethers by reaction with difluorocarbene source, trimethylsilyl 2-fluorosulfonyl-2,2-difluoroacetate (TFDA). These ethers are then converted in high yield to the respective naphthols by heating with a mixture of acetic acid and 48% HBr.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Xiaohong Cai, Kai Wu, William R. Jr.,