Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10573980 | Journal of Inorganic Biochemistry | 2005 | 9 Pages |
Abstract
Palladium(II) complexes of 2-benzoylpyridine thiosemicarbazone (H2Bz4DH) and its N(4)-methyl (H2Bz4M) and N(4)-phenyl (H2Bz4Ph) derivatives were obtained and fully characterized. [Pd(2Bz4DH)Cl] (1) crystallizes in the monoclinic space group P21/c with a = 11.671(1), b = 10.405(1), c = 13.124(1), β = 115.60(1)° and Z = 4; [Pd(2Bz4M)Cl] (2) in the monoclinic space group P21/c with a = 9.695(1), b = 15.044(1), c = 10.718(1) Ã
, β = 105.38(1)° and Z = 4 and [Pd(2Bz4Ph)Cl] (3) in the triclinic space group P1¯ with a = 9.389(1), b = 13.629(1), c = 15.218(1) Ã
, α = 70.25(1), β = 73.46(1), γ = 83.57(1)° and two independent molecules per asymmetric unit (Z = 4). All complexes show a quite similar planar fourfold environment around palladium(II). A negatively charged organic molecule acts as a tridentate ligand and binds to the metal through the pyridine nitrogen, the imine nitrogen and the sulfur atom. A chloride ion occupies the fourth coordination site. The planar complexes stack nearly parallel to one another in the lattice conforming a layered crystal structure. The cytotoxic activity of the thiosemicarbazones and their metal complexes was tested against the MCF-7, TK-10 and UACC-62 human tumor cell lines. The ligands exhibit lower values of GI50 and LC50 than the complexes, H2Bz4Ph being the most active with GI50 < 0.003 μM; LC50 = 13.4 μM; GI50 = 9.3 μM, LC50 = 12.9 μM; GI50 < 0.003, LC50 = 13.8 μM in the MCF-7, TK-10 and UACC-62 cell lines, respectively. Among the complexes, [Pd(2Bz4Ph)Cl] (3) exhibited the lowest values of GI50 in the three studied cell lines.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Anayive P. Rebolledo, Marisol Vieites, Dinorah Gambino, Oscar E. Piro, Eduardo E. Castellano, Carlos L. Zani, Elaine M. Souza-Fagundes, LetÃcia R. Teixeira, Alzir A. Batista, Heloisa Beraldo,