Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10574322 | Journal of Inorganic Biochemistry | 2005 | 7 Pages |
Abstract
A new ligand L, 1-[3-(2-pyridyl)pyrazol-1-ylmethyl]naphthalene, and its two metal complexes, [Cu(L)3](ClO4)2 (1) and [Zn(L)3](ClO4)2(H2O)2 (2), have been synthesized and characterized. The crystal structure of complex 1 was determined by single crystal X-ray diffraction, which crystallized in monoclinic, space group P21/n with unit cell parameters, a = 12.710(4) Ã
, b = 12.135(3) Ã
, c = 33.450(9) Ã
, β = 93.281(5)° and Z = 4. The Cu atom was six-coordinated to N(1), N(2), N(4), N(5), N(7) and N(8) from three L ligands and formed a slightly distorted octahedral geometry. Complexes 1 and 2, and ligand L were subjected to biological tests in vitro using three different cancer cell lines (HL-60, BGC-823 and MDA-MB-435). Complex 1 showed significant cytotoxic activity against three cancer cell lines. The interactions of complexes 1 and 2, and ligand L with calf thymus DNA were then investigated by thermal denaturation, viscosity measurements and spectrophotometric methods. The experimental results indicated that complexes 1 and 2 bound to DNA by intercalative mode via the ligand L. The intrinsic binding constants of complexes 1 and 2, and ligand L with DNA were 1.8 Ã 104, 5.4 Ã 103 and 2.76 Ã 103 Mâ1, respectively.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Hang Zhang, Chun-Sen Liu, Xian-He Bu, Ming Yang,